Application Notes
Cellix's versatile system has been validated across a range of therapeutic areas including oncology, immunology, bacteriology, respiratory and cardiovascular biology and is currently being used by over a third of the top ten pharmaceutical companies worldwide.
Cardiovascular
C100: The adhesion profile of platelets and shear-dependent thrombus formation mechanisms were investigated, on different substrates such as vWF and collagen, using whole blood samples.
Immunology
I200: An investigation of Inflammation focused on Leukocyte Adhesion: Quantifying adhesion, inhibition and stimulation.
I100: An investigation of adhesion to T-cells to ICAM-1 when treated with a range of statins under physiological flow.
Oncology
O100: Cell adhesion was investigated within an isogenic model of melanoma progression highlighting the importance played by shear stress.
Bacteriology
B100: Shear stress plays a fundamental role in bacterial adhesion and colonization, as elucidated in this study with regards to E.coli adhesion and spreading on mono- and tri-mannose coated surfaces.
Respiratory
R200: Tthe effect of levocetirizine on human eosinophil adhesion to VCAM-1 and BSA was assessed.
R100: Novel anti-inflammatory effects of Montelukast on human eosinophils were investigated in this study, mimicking physiological adhesion to VCAM-1 under flow conditions.