Immunology
| Integrins are protein receptors that connect the extracellular environment with intracellular signaling events in a cell. Integrins are important for normal development and function, but are also involved in the pathogenesis of diseases including cancer, autoimmunity, rheumatoid arthritis, crohn's disease and heart disease. It is important to understand the normal adhesion profiles of leukocytes so as to identify their role in disease states. | |
Inflammation:Role played by key adhesion molecules in inflammatory diseasesInflammation is an adaptive response that is triggered by noxious stimuli and conditions, such as infection and tissue injury. In this study we present data on the adhesion profiles of monocytes and PBMCs on a range of adhesion molecules and on endothelial cells, analyzing the role of these proteins and other chemokines, which are involved in various stages of inflammation and leukocyte trafficking, under physiological flow conditions using Cellix’s VenaFluxTM microfluidic platform. Statins are cholesterol-reducing drugs that have become a
cornerstone of primary and secondary prevention of cardiovascular
disease. In recent years, pleiotropic effects of statins have been
highlighted including immunomodulatory properties in conditions as
diverse as rheumatoid arthritis and COPD. Statins exert these effects
on the inflammatory responses in part through modulating lymphocyte
adhesion to endothelial cells. |
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Rolling of THP1 monocytes subjected to 0.5 dyne cm² on E-selectin
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Immunomodulation:Screening statin drugs for their potential treatment of sepsisSepsis continues to be an increasingly frequent and acute medical problem in critically ill patients in the intensive care unit. Experimental evidence in animals has indicated that statins may prevent sepsis and modulate its severity. Statins are proposed to inhibit the binding of T-cells to ICAM-1 on endothelial cells.Using Cellix's VenaFlux Platform, the adhesion profile of statin-treated T-cells from a mixed-sepsis model was assessed. |
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