Oncology Drug Screening Tool that eliminates false leads earlier |
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Execute continuous flow cell based assays and advanced transmigration assays superseding existing transwell migration assay |
| The VenaFlux Platform from Cellix is ideal for the study of cancer cell movemnet in an in-vitro experimnetal set up mimicking in-vivo conditions of the blook vessel. Using live cell imaging, interactions of cancer cellis with proteins of the blood vessel wall can be visualised using Vena8 biochips while cell-cell interactions can be investigated using VenaEC biochips. These key prerequisite steps to transmigration give researchers a greater understanding of how cancer cells move out of the human blook vessel before developing into secondary tumors. Cellix have validated their technology in the following areas: Melanoma and Breast Cancer. Both are of particular interest due to the high metastic potential. Cellix's technology provides a key future reasearch tool for this area. |
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MelanomaCellix model physiological conditions of blood vessels to mimic metastasisMelanoma is the most aggressive form of skin cancer, which invades
deeper layers of the skin and has a propensity to metastasise early.
Cellix provides an ideal platform to screen genetic variants of
metastatic cells and to evaluate their metastatic potential. |
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Intravital microscopy of HT1080-GFP tagged fibrosacroma tumour
cells rolling. Video courtesy of Prof. Robert Hoffman (Anti-Cancer
Inc.) and Prof. William Gallagher (University College Dublin) |
Breast CancerCellix model transmigration capabilities of the highly metastatic breast cancer cells An advanced physiological transmigration assay can be performed using Cellix's chemotaxis assay biochip. As cells flow in the microcapillaries of the biochip, the cells begin to roll, adhere and transmigrate towards the chemo-attractant. Cellix's transmigration assay supersedes the existing transwell migration assay due to its robustness and defined physiological stresses subjected to the flowing cells. Cellix's system is also used as a screening tool for putative cancer drug therapies, via the inhibition of adhesion and transmigration of metastatic cancer cells. |
O200 Intravital microscopy of HT1080-GFP tagged fibrosacroma
tumour cells showing extravasation. Video courtesy of Prof. Robert
Hoffman (Anti-Cancer Inc.) and Prof. William Gallagher (University
College Dublin) |
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