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University of Aberdeen
Cellix, in collaboration with Dr. Helen Galley and Dr. Damon Lowes Department of Medicine Therapeutics, University of Aberdeen, undertook an investigation of T-cell adhesion to ICAM-1 with a mixed sepsis model due to the increasingly frequent and acute medical problem in critically ill patients in the intensive care unit despite significant advances in management and treatment.
Objectives
Investigatin of T-cell adhesion to ICAM-1 using a mixed sepsis model treated with a range of statins (pravastatin, fluvastatin, mevastatin, lovastatin, simvastatin) under physiological shear stress using Cellix Products.
Equipment Used
Results
LPS/PEPG stimulated cells treated with all statins used in the study caused a statistically significant reduction in adhesion when compared to the LPS/PegP stimulated control. However, simvastatin treated cells nearly always tended to aggregate even at pM concentrations.Acknowledgements
Cellix would like to thank Dr. Helen Galley and Dr. Damon Lowes, Department of Medicine Therapeutics, Institute of Medical Sciences, University of Aberdeen, Scotland for their experimental design and time throughout this collaboration.