Cellix's biochips and pumping solutions enable researchers to perform in-vitro assays mimicking in-vivo conditions of the blood vessel, providing powerful physiologically relevant data before compounds reach clinical trials. Below, you will find a selection of movies from different therapeutic areas such as thrombosis, atherosclerosis, inflammation, oncology (melanoma and breast cancer), bacteriology and respiratory.
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Thrombosis: Platelet adhesion from whole blood on collagen coated biochips at 60 dyne/cm²
Thrombosis: Platelet adhesion from whole blood on collagen coated biochips at 30 dyne/cm²
Thrombosis: Platelet adhesion to vWF coated biochip at 60 dyne/cm
Thrombosis: Platelet-leukocyte interaction on collagen coated biochips at 2.25 dyne/cm²
Thrombosis: Platelet-leukocyte interaction at 2.25 dyne/cm² on collagen coated biochip
Thrombosis: Platelet adhesion from whole blood to collagen coated biochip at 60 dyne/cm²
Atherosclerosis Movies
Inflammation - Atherosclerosis: THP-1 monocytes adhering to HUVECs in biochip under flow
Atherosclerosis: primary monocyte adhesion to coronary artery endothelium under shear flow
Inflammation - Atherosclerosis: Tracking of THP-1 monocytes rolling on E-selectin coated biochip
Leukocyte Rollling of THP1 monocytes on E-selectin coated microchannel at 0.5 dyne/cm²
Inflammation Movies
Inflammation: PMA stimulated T-cells adhering to non-stimulated HUVECs under shear flow
Inflammation: Pravastatin-treated PBL cells rolling (not adhering to) on VCAM-1
Inflammation Control Experiment: HUT78 T-cells not adhering in BSA coated biochip at 0.5 dyne/cm²
Oncology Movies
Oncology-Melanoma: GFP-tagged 1205Lu melanoma cells adhering to non-stimulated HUVECs under shear flow
Intravital microscopy of HT1080-GFP tagged fibrosacroma tumour cells rolling. Video courtesy of Prof. Robert Hoffman (Anti-Cancer Inc.) and Prof. William Gallagher (University College Dublin)
Oncology - Breast Cancer: GFP-tagged MDA cancer cells adhering to non-stimulated HUVECs under flow
Breast Cancer: MDA cells adhering to TNF-alpha stimulated HUVECs under shear flow in microfluidic biochip
Bacteriology Movie
K12 bacteria flowing, rolling and adhering to monomannose coating at 0.3, 1.0 and 8.0 dyne/cm², respectively
Respiratory Movie
Inflammation - Asthma / COPD: Eosinophil Adhesion to HMVEC-L at 0.5 dyne/cm²