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Interleukin-33 Induces Expression of Adhesion Molecules and Inflammatory Activation in Human Endothelial Cells and in Human Atherosclerotic Plaques
Svitlana Demyanets, Viktoria Konya, Stefan P. Kastl, Christoph Kaun, Sabine Rauscher, Alexander Niessner, Richard Pentz, Stefan Pfaffenberger, Kathrin Rychli, Christof E. Lemberger, Rainder de Martin, Akos Heinemann, Ihor Huk, Marion Groger, Gerald Maurer, Kurt Huber, Johann Wojta.
It was shown that "inflammatory activation of human endothelial cells by IL-33 by showing that this cytokine, which we found to be expressed in human atherosclerotic tissue, stimulates adhesion of leukocytes to the endothelium under static and flow conditions and upregulates the expression of the adhesion molecules ICAM-1, VCAM-1 and E-selectin and of the chemokine MCP-1 in human endothelial cells in vitro."
Cellix's Mirus Nanopump and microfluidic biochips were used in this study to perform Human polymorph-nuclear leukocyte (PMNL; 99% neutrophils and less than 1% eosinophils) or monocyte adhesion to Human Coronary Artery Endothelial Cells (HCAEC) under flow conditions; see Fig 1, p2083.
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