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Vena8

The Vena8™ biochip is ideal for studying cell receptor-ligand interaction.  As cells flow through the microcapillary of the Vena8™ biochip, the cell surface receptors may interact with adhesion molecules or ligands which coat the microcapillary walls. Ideal for phase-contrast imaging.
Vena8 biochip
Illustration close-up:
Cell adhesion inside ligand-coated microchannel of Vena8 biochip
Example:  Adhesion of RBCs infected with malaria parasite to ICAM-1 coated channel at shear stress of 0.5 dyne/cm2

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Red Blood Cells infected with malaria flowing through ICAM coated biochip at 0.5 dyne/cm²
Tracking of THP-1 monocytes rolling on E-selectin coated biochip under shear flow using Image-Pro Plus software.
   
Inflammation: Pravastatin-treated PBL cells rolling (not adhering to) on VCAM-1
Leukocyte Rollling of THP1 monocytes on E-selectin coated microchannel at 0.5 dyne/cm²  
 
   
Inflammation Control Experiment: HUT78 T-cells not adhering in BSA coated biochip at 0.5 dyne/cm²  
 
 
Each biochip contains 8 capillaries in parallel which can be coated with different adhesion molecules for cell receptor-ligand (i.e. cell-matrix interactions) studies under shear flow. Each 10 pack contains 80 assays. Each 5 pack contains 40 assays.
 

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