Therapeutic Areas
Breast Cancer
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Cellix model transmigration of the highly metastatic breast cancer cells
An advanced physiological transmigration assay can be performed using Cellix's upcoming chemotaxis assay biochip. As cells flow in the microcapillaries of the biochip, the cells begin to roll, adhere and transmigrate towards the chemo-attractant. Cellix's transmigration assay supersedes the existing transwell migration assay due to its robustness and defined physiological stresses subjected to the flowing cells. Cellix's system is also used as a screening tool for putative cancer drug therapies, via the inhibition of adhesion and transmigration of metastatic cancer cells.
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Oncology - Breast Cancer: GFP-tagged MDA cancer cells adhering to non-stimulated HUVECs under flow
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Breast Cancer: MDA cells adhering to TNF-alpha stimulated HUVECs under shear flow in microfluidic biochip
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Intravital microscopy of HT1080-GFP tagged fibrosacroma tumour cells rolling. Video courtesy of Prof. Robert Hoffman (Anti-Cancer Inc.) and Prof. William Gallagher (University College Dublin)
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